Viartril®-S is the Crystalline Glucosamine Sulfate. It is the original and only Glucosamine Sulfate that has been fully tested in clinical trials for safety and efficacy.Clinical studies and the world-wide clinical experience have shown that Viartril®-S relieves the symptoms (pain and function limitation) of osteoarthritis. Recent, state-of-the-art clinical trials have also demonstrated that Viartril®-S is the first compound that, when given for long-term treatment courses (i.e. at least 3 years), can decrease the progression of osteoarthritis. How does Viartril®-S work? Anabolic-Effect – Viartril®-S stimulates the synthesis of proteoglycans, the building blocks of the Cartilage Matrix. Anti-Inflammatory & Anti-Catabolic – Viartril®-S depress cartilage degradation activities by inhibiting the action of catabolic enzymes. What is Glucosamine Sulfate? Glucosamine Sulfate is the salt of the natural amino-sugar glucosamine, which is normally synthesized in the healthy body and is the preferred substances that form the cartilage matrix that are essential for cartilage health and function.